Radiesse is most frequently used to treat hollowness or deep folds in the lower and mid face. Sunken cheeks, nasolabial folds and marionette lines can all be treated with Radiesse. The active ingredient in Radiesse, calcium hydroxylapatite, and it is a thicker dermal filler than many other options on the market, which makes it particularly suitable for significant volume loss or sagging, crepey skin.